Quarterback Carson Wentz of the Philadelphia Eagles will make his first start of the season against the Indianapolis Colts on Sunday, but he won't have running backs Jay Ajayi or Darren Sproles in the backfield with him.
Ajayi (back) and Sproles (hamstring) both were ruled out of the game by the Eagles on Friday. Sproles also missed last week's game against the Tampa Bay Buccaneers because of the injury, while Ajayi injured his back in that defeat.
In two games, Ajayi has 85 yards rushing and three touchdowns on 22 carries.
"It doesn't affect play calling, it just affects personnel in the game, because like you said, we're down some bodies, " head coach Doug Pederson said of the injuries.
"Look, we don't make excuses for it. It's part of the National Football League. Injuries are going to happen each and every week, and we've got to get the next guy ready to go."
Running back Corey Clement (quad) is listed as questionable and he is expected to play, but if he can't go, the Eagles will be down to Wendell Smallwood and Josh Adams in the backfield.
The Eagles also listed linebacker Kamu Grugier-Hill (groin), wide receiver Alshon Jeffery (shoulder) and left tackle Jason Peters (guard) as questionable.
Pederson said Jeffery has not been cleared for contact, while Peters was a full participant in practice.