The Chargers started with the football, going three-and-out on their first possession.
Buffalo's offense took advantage. Wide receiver Stefon Diggs drew a 47-yard defensive pass interference penalty, which gave the Bills the ball at the Chargers' five-yard line. Two plays later, quarterback Josh Allen hit tight end Dawson Knox for a two-yard touchdown to give Buffalo an early 7-0 lead.
The Chargers responded with a 13-play, 79-yard drive that included five touches for 45 yards from running back Austin Ekeler - his first game since Week 4 at Tampa Bay. It was capped with a five-yard touchdown pass from quarterback Justin Herbert to wide receiver Keenan Allen. A missed extra point made the score 7-6 Buffalo.
The touchdown was Allen's seventh of the season, the most since he caught eight scores his rookie season in 2013.